The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex

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The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex

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The sperm-specific CatSper channel controls the intracellular Ca(2+) concentration ([Ca(2+)](i)) and, thereby, the swimming behaviour of sperm. In humans, CatSper is directly activated by progesterone and prostaglandins-female factors that stimulate Ca(2+) influx. Other factors including neurotransmitters, chemokines, and odorants also affect sperm function by changing [Ca(2+)](i). Several liga...

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ژورنال

عنوان ژورنال: ACS Chemical Biology

سال: 2015

ISSN: 1554-8929,1554-8937

DOI: 10.1021/acschembio.5b00748